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“绿色制药前沿论坛”第三十二讲预告
来  源: 绿色制药协同创新中心 日  期: 2018-03-22 点击率: 385
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    题目: Engineered Biosynthesis of Medicinal Natural Products
    主讲人:Ikuro Abe (日本东京大学)                                          
    时间:2018年4月5日(星期四)16:00-17:00
    地点: 新教1006室
    
    讲座内容简介(Abstract):
    Meroterpenoids are hybrid natural products that are partially derived from terpenoids, and those from fungi exhibit an extremely wide range of structural diversity and biological activities. Recent advances in genome sequencing technologies and development of tools for biosynthetic studies have allowed the discovery of many biosynthetic gene clusters for fungal meroterpenoids and intensive researches at genetic and enzymatic level. We have been working on the meroterpenoids derived from a simple aromatic precursor, 3,5-dimethylorsellinic acid (DMOA), and discovered several fascinating enzymes that catalyze drastic structural rearrangement which dramatically increase structural complexity of the molecules. For example, multifunctional, non-heme iron dependent oxygenases are the key components in the austinol and the paraherquonin pathway, in which the enzymes are responsible for the construction of the spiro-lactone and cycloheptadiene moiety, respectively. On the other hand, the terretonin biosynthesis involves a cytochrome P450 and an isomerase, which work collaboratively to perform the unprecedented ring expansion reaction to afford the terretonin scaffold. This presentation will focus on molecular basis for the unusual ring reconstruction reactions in fungal meroterpenoid biogenesis.
    主讲人简介:
    Ikuro Abe,博士,教授,天然药物化学专业,天然药物生物合成开发与工程实践研究方向; 1984年获得东京大学学士学位,1986年获得东京大学硕士学位,1989年获得东京大学博士学位,1989-1991年在法国科学研究中心天然药物化学研究所进行博士后研究。1991-1996年纽约州立大学研究助理教授,1996-1998年犹他大学研究助理教授。Abe教授长期从事植物多酚类次生代谢物的生物合成研究,在Nature, Nature Chemical Biology, NatureCommunication, JACS 以及PNAS等世界顶级杂志发表40多篇。现为《Natural Product Reports》、《Frontiers in Plant Science》、《Natural Products and Bioprospecting》、《Journal of Chinese Pharmaceutical Sciences》编委;《TERPNET》执行编委;连续三届担任PACIFICHEM, Biosynthesis of Natural Products会议主席。